Rome IV criteria define dyspepsia as having one or more of the following symptoms
Functional dyspepsia based on the Rome IV criteria is defined as the presence of one or more of the following symptoms plus no evidence of structural disorder from upper endoscopy to explain the symptoms
Functional dyspepsia or non-ulcer dyspepsia can be subclassified into 2 types of conditions.
While patients with these symptoms and a negative diagnostic evaluation likely have functional dyspepsia, according to the Rome IV guidelines, the criteria should be fulfilled for the last three months with symptom onset at least six months before diagnosis. Patients with functional dyspepsia must also fulfil criteria for PDS or EPS.
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The cause of dyspepsia can be idiopathic (functional) or with a secondary cause (25%). Secondary cause of dyspepsia include:
Functional dyspepsia (Non-ulcer dyspepsia) is when dyspepsia has no cause (idiopathic)
Many mechanisms have been proposed but the pathogenesis of functional dyspepsia is still unclear. Some of the possible mechanism for functional dyspepsia are as follows:
As mentioned, non-ulcer dyspepsia is a diagnosis of exclusion. They can only be definitive diagnosed with upper endoscopy when other causes of epigastric pain are ruled out.
The diagnosis of functional (idiopathic or nonulcer) dyspepsia is made from the characteristic clinical history of postprandial fullness, early satiety, or epigastric pain/ burning for the last three months with symptom onset at least six months before diagnosis and the exclusion of other causes of dyspepsia with upper endoscopy and additional testing, if indicated, based on the symptoms.
Gastroesophageal reflux disease can often be confused with functional dyspepsia, as dyspepsia symptoms commonly coexist with heartburn, and some patients with functional dyspepsia respond to PPI therapy. Gastroparesis is rare but can also be confused with functional dyspepsia, as gastric emptying may be slow and symptoms of dyspepsia occur in both disorders; vomiting or weight loss with very slow gastric emptying suggest gastroparesis
For patient under the age of 45 years old with no alarming symptoms like (weight loss, anemia, dysphagia), they are managed empirically with proton pump inhibitors (PPI) like Protonix. In situations where PPI are not available, Histamine receptor-2 blockers (H2 blocker), liquid antacid can be used instead although they have less efficacy.
Initial therapy for patients with functional dyspepsia is PPI. In addition, if local prevalence of H.pylori is > 10%, there is a need to test for and treat H.pylori if present. If negative should be treated with PPI empirically if local prevalence of H.pylori < 5%. If prevalence is intermediate, your doctor may choose to do either just PPI or with H.pylori tesing inclusive.
If patients’ symptoms are refractory to 8 weeks of PPI, therapeutic trial with tricyclic antidepressant (TCA) should be initiated. Amitriptyline (50 mg), escitalopram (10 mg) are commonly used.
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